4.8.2021 – Angela’s manuscript, Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis, is published in ChemMedChem.
4.5.2021 – Jiachen’s manuscript, Medulloblastoma Drugs in Development: Current Leads, Trials, and Drawbacks, is published in European Journal of Medicinal Chemistry.
3.26.2021 – Seema Patel receives a Goldwater Scholarship. Congratulations Seema!!!
3.15.2021 – Chris’ manuscript, Targeting the GLI Family of Transcription Factors for the Development of Anti-Cancer Drugs, is published in Expert Opinion on Drug Discovery.
1.30.2021 – Seema’s manuscript, Translesion Synthesis Inhibitors as a New Class of Cancer Chemotherapeutics, is published in Expert Opinion on Investigational Drugs.
1.15.2021 – RC’s manuscript, Structure-Based Virtual Screening Identifies the 8-hydroxyquinolie Scaffold as a New Class of GLI1 Inhibitors, is published in Molecular Therapy Oncolytics.
12.19.2020 – Seema Patel receives designation as a UConn University Scholar. Congratulations Seema!!!
10.15.2020 Our collaborative manuscript with the Peczuh Lab at UConn, Exploring the Physicochemical and Antiproliferative Properties of Biaryl-Linked [13]-Macrodilactones, is published in Bioorganic & Medicinal Chemistry.
7.30.2020 – Our collaborative manuscript with the Tang Lab at UConn, Small Molecules Block the Interaction Between Porcine Reproductive and Respiratory Syndrome Virus and CD163 Receptor and the Infection of Pig Cells is published in BMC Virology Journal.
6.18.2020 – Our collaborative manuscript with the Cimprich lab at Stanford, HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis, is published in Molecular Cell.
6.10.2020 – Our collaborative manuscript with the Cantor lab at UMass Medical School, Inhibition of Translesion Synthesis Polymerase Rev1 exploits Replication Gaps as a Cancer Vulnerability, is published in Science Advances.
5.18.2020 – Kyle and Angela’s manuscript, Introduction to Medicinal Chemistry: A Five-Day Course for High School Students, is published in Journal of Chemical Education.
5.1.2020 – Seema receives a Summer Undergraduate Research Fellowship (SURF) from UConn for Summer 2020.
2.1.2020 – A collaborative R01 grant with Sharon Cantor at UMass Medical School has been funded by the NIH/NCI.
1.21.2020 – Angela’s manuscript, Probing the Protein-Protein Interaction Between the ATRXADD Domain and the Histone H3 Tail, is published in Molecules.
1.10.2020 – Jiachen’s manuscript, Inhibition of Hedgehog Signaling by Sterochemically Defined Des-Triazole Itraconazole Analogues, is published in Bioorganic & Medicinal Chemistry Letters.
10.2.2019 – Jen’s manuscript, Formulation and Evaluation of Itraconazole Liposomes for Hedgehog Pathway Inhibition, is published in Journal of Liposome Research.
9.19.2019 – In collaboration with the White lab in the Department of Molecular and Cellular Biology at UConn, the Hadden lab has received a SPARK award to explore the antiviral activity of itraconazole and related analogues developed in the lab.
9.1.2019 – Kyle joins the Editorial Board of the Bioorganic Chemistry Section of Molecules.
8.23.2019 – Jiachen’s manuscript, Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-Like Properties, is published in ACS Medicinal Chemistry Letters.
7.30.2019 – RC’s manuscript, Virtual Pharmacophore Screening Identifies Small-Molecule Inhibitors of the Rev1-CT/RIR Protein-Protein Interaction, is published in ChemMedChem.
7.1.2019 – The Hadden lab received a grant from the UConn Research Foundation for a project to develop Gli1 inhibitors as anti-cancer agents.
6.1.2019 – In collaboration with the Korzhnev lab at the UConn Health Center, the Hadden lab has received an award from the NIH/NCI to continue the development of promising lead scaffolds as small molecule inhibitors of translesion synthesis.
3.21.2019 – Jen’s manuscript, Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors, is published in Journal of Medicinal Chemistry.
2.1.2019 – Kelly’s manuscript, Development of Posaconazole-Based Analogues as Hedgehog Signaling Pathway Inhibitors, is published in European Journal of Medicinal Chemistry.
1.7.2019 – Chad’s manuscript, Synthesis and Evaluation of Third Generation Vitamin D3 Analogues as Inhibitors of Hedgehog Signaling, is published in European Journal of Medicinal Chemistry.
1.2.2019 – Evrett’s manuscript, Probing Seco-Steroid Inhibition of the Hedgehog Signaling Pathway, is published in Molecular and Cellular Biochemistry.
10.5.2018 – RC’s manuscript, Structural Approach to Identify a Lead Scaffold that Targets the Translesion Synthesis Polymerase Rev1, is published in Journal of Chemical Information and Modeling.
8.1.2018 – Zu and RC’s manuscript, Small Molecule Scaffolds that Disrupt the Rev1-CT/RIR Protein-Protein Interaction, is published in Bioorganic and Medicinal Chemistry.
5.2.2018 – RC’s manuscript, A Metadynamic Approach to Understand the Recognition Mechanism of the Histone H3 Tail with the ATRXADD Domain, is published in BBA Gene Regulatory Mechanisms.
3.16.2018 – Shana receives a Summer Undergraduate Research Fellowship to continue her work on itraconazole-mediated smoothened localization this summer. Congratulations Shana!!!
3.2.2018 – Jiachen’s manuscript, Structure-Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors, is published in ChemMedChem.
1.11.2018 – Chad successfully defends his PhD dissertation. He is heading to a postdoctoral position at Purdue University with Prof. Emily Dykhuizen. Congratulations and Good Luck!!!
12.7.2017 – Jen successfully defends her PhD dissertation. She is heading to a postdoctoral position at Tufts University with Prof. Joshua Kritzer. Congratulations and Good Luck!!!
6.1.2017 – Kelly’s manuscript, Methyllysine Binding Domains: Structural Insight and Small Molecule Probe Development is published in European Journal of Medicinal Chemistry.
5.1.2017 – The Hadden lab has received grant support from the Program in Innovative Therapeutics for Connecticut’s Health to develop inhibitors of translesion synthesis.
3.1.2017 – Divya Chennamadhavuni joins the Hadden lab as a postdoctoral researcher. Welcome Divya!!!
2.1.2017 – RC’s manuscript, A Molecular Dynamics Approach to Identify an Oxysterol-Based Hedgehog Pathway Inhibitor, is published in Biochimica et Biophysica Acta – General Subjects.
12.5.2016 – Kaitlyn was named the December/January UConn School of Pharmacy Student Researcher of the Month. Congratulations Kaitlyn !!!
11.1.2016 – Jiachen Wen joins the Hadden lab as a postdoctoral researcher. Welcome Jiachen!!!
8.1.2016 – Angela Zaino joins the Hadden lab as a graduate student. Welcome Angela!!!
7.20.2016 – Kyle and Dmitry’s review on targeting translesion synthesis for anti-cancer drug development is published in Journal of Medicinal Chemistry.
5.25.2016 – Jen Pace is awarded an ACS Medicinal Chemistry Division Predoctoral Fellowship. Congratulations Jen!!!
5.23.2016 – Zuleyha Ozen joins the Hadden lab as a Research Technician. Welcome Zuleyha!!!
5.12.2016 – Jen and Al’s manuscript, Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic, is published in Journal of Medicinal Chemistry.
4.15.2016 – Chad’s manuscript, Synthesis and Evaluation of Osteogenic Oxysterols as Hedgehog Pathway Activators, is published as the highlighted front cover article in ChemMedChem.
3.15.2016 – RC Dash joins the Hadden lab as a new Postdoctoral Researcher. Welcome RC!!!
1.15.2016 – Kaitlyn McCarthy joins the Hadden lab as an undergraduate/Pharmacy student researcher.
12.18.2015 – Kelly Chan was named a UConn University Scholar. Congratulations Kelly!!!
12.1.2015 – Chad and Jen’s review article has been published in Current Medicinal Chemistry.
11.2.2015 – Kelly Teske joins the Hadden lab as a new Postdoctoral Researcher. Welcome Kelly!!!
10.1.2015 – Kelly Chan received the inaugural Antipas Family Research Scholarship in the UConn School of Pharmacy. Congratulations Kelly!!!
8.1.2015 – The Hadden lab has been awarded a grant from the National Science Foundation to explore the mechanisms through which calcitriol regulates Hh signaling during embryonic development.
3.13.2015 – Kelly has been awarded a UConn SURF Award for Summer 2015. Congratulations Kelly!!!
2.20.2015 – Al’s manuscript, Vitamin D3 Analogues that Contain Modified A- and Seco-B-Rings as Hedgehog Pathway Inhibitors, has been published in European Journal of Medicinal Chemistry.
1.20.2015 – Raymond Tran joins the Hadden lab as an undergraduate/Pharmacy student researcher.
12.29.2014 – Upasana’s manuscript, Design, Synthesis, and Evaluation of Hybrid Vitamin D3 Side Chain Analogues as Hedgehog Pathway Inhibitors, has been published in Bioorganic and Medicinal Chemistry.
12.12.2014 – In collaboration with Robert Wechsler-Reya, the Hadden lab has received a grant from the National Institutes of Health to develop itraconazole analogues as hedgehog pathway inhibitors for the treatment of medulloblastoma.
12.11.2014 – Evrett Thompson was named to the UConn University Scholars Program. Congratulations Evrett!!!
9.19.2014 – Upasana successfully defends her Ph.D dissertation. Congratulations Upasana!!!
8.28.2014 – Kelly Chan joins the Hadden lab as an undergraduate/Pharmacy student researcher.
8.01.2014 – Upasana and Kyle’s review, Recent Advances in the Design of Hedgehog Pathway Inhibitors for the Treatment of Malignancies, has been published in Expert Opinion on Drug Discovery.
5.8.2014 – Hadden lab research on Vitamin D3 analogues that target the Hh signaling pathway has been highlighted in an article on the American Cancer Society website.
4.29.2014 – Dan Raccuia was awarded a Pharm.D. Research Grant from the UConn School of Pharmacy for Summer/Fall 2014. Congratulations Dan!!!
4.14.2014 – Al’s manuscript, Structure-Activity Relationships for Vitamin D3-Based A-Ring Analogues as Hedgehog Pathway Inhibitors, has been published in Journal of Medicinal Chemistry.
1.20.2014 – Evrett Thompson joins the Hadden lab as an undergraduate researcher.
1.03.2014 – Kyle’s manuscript, Hedgehog Pathway Agonism: Therapeutic Potential and Small-Molecule Development, has been published in ChemMedChem.
12.19.2013 – Audrey Corman was awarded her second Pharm.D. Research Grant from the UConn School of Pharmacy for Spring 2014. Congratulations Audrey!!!
9.2.2013 – Al’s manuscript, Analogues of the Inhoffen-Lythgoe Diol with Anti-Proliferative Activity, has been published in Bioorganic and Medicinal Chemistry Letters.
8.26.2013 – In collaboration with Dmitry Korzhnev at UCHC, the Hadden lab received a CICATS Pilot Grant for a project titled “Translesion Synthesis DNA Polymerases as Targets for Anti-Cancer Drug Design.”
8.15.2013 – Al’s manuscript, Identification of Vitamin D3-Based Hedgehog Pathway Inhibitors That Incorporate an Aromatic A-Ring Isostere, has been published in ACS Medicinal Chemistry Letters.
7.1.2013 – Chad Maschinot and Jennifer Pace join the Hadden lab as new graduate students in Medicinal Chemistry
6.01.2013 – Dan Raccuia joins the Hadden lab as an undergraduate researcher.
3.25.2013 – The Hadden lab was awarded an American Cancer Society Research Scholar Award for a project titled “Vitamin D3 Analogues as Hedgehog Pathway Inhibitors.”
3.15.2013 – Dan Madden received a 2013 Summer Undergraduate Research Fellowship from UConn. Congratulations Dan!!!
3.12.2013 – Michele was named Student Researcher of the Month in the School of Pharmacy for March. Congratulations Michele!!!