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Hadden Research Lab

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Hadden Research Lab
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  • Research
    • Vitamin D3 Analogues as Hedgehog Pathway Inhibitors
    • Identifying Novel Cellular Targets of VD3 and Calcitriol
    • Oxysterols as Hh Pathway Agonists
    • Repurposing Itraconazole as an Anti-Cancer Agent
    • Computational Modeling of the Smoothened Receptor
    • Translesion Synthesis Inhibitors as Anti-Cancer Agents
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Recent News

10.30.2019 – Jiachen’s manuscript on stereochemically-defined itraconazole analogues is published in Bioorg. Med. Chem. Lett.

10.2.2019 – Jen’s manuscript on itraconazole liposomes is published in J. Liposome Res.

9.19.2019 – The Hadden lab receives a SPARK Technology Award from UConn.

8.23.2019 Jiachen’s manuscript on truncated itraconazole analogues is published in ACS Med Chem Lett.

 

 

About the Hadden Lab

The long-term goal of research in the Hadden lab is to utilize a medicinal chemistry/chemical biology approach to understand the mechanisms through which dysregulation of cellular signaling pathways contributes to the onset of human cancer and to apply this knowledge to develop improved therapeutics that target these pathways. To this end, we use a combination of organic synthesis and molecular biology techniques to prepare and evaluate small molecule modulators of these therapeutic targets. Major ongoing projects include the development of hedgehog pathway modulators as therapeutic agents and the development of small molecule inhibitors of translesion synthesis.

We are always interested in hearing from potential graduate students or postdoctoral researchers, especially those who have their own funding. Please contact Professor Hadden if you are interested in our research or want to discuss the possibility of open positions.

Contact Information

Phone: 860-486-8446
E-mail: kyle.hadden@uconn.edu
Address: 69 N Eagleville Rd
Unit 3092
Storrs, CT 06269
Pharmacy & Biology Building
Office - PBB 628
Labs - PBB 510, 512, and 516
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