Jiachen’s manuscript, Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-Like Properties, is published in ACS Medicinal Chemistry Letters

RC’s manuscript, Virtual Pharmacophore Screening Identifies Small-Molecule Inhibitors of the Rev1-CT/RIR Protein-Protein Interaction, is published in ChemMedChem.

The Hadden lab received a grant from the UConn Research Foundation for a project to develop Gli1 inhibitors as anti-cancer agents.

In collaboration with the Korzhnev lab at the UConn Health Center, the Hadden lab has received an award from the NIH/NCI to continue the development of promising lead scaffolds as small molecule inhibitors of translesion synthesis.

Jen’s manuscript, Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors, is published in Journal of Medicinal Chemistry.

Kelly’s manuscript, Development of Posaconazole-Based Analogues as Hedgehog Signaling Pathway Inhibitors, is published in European Journal of Medicinal Chemistry.

Chad’s manuscript, Synthesis and Evaluation of Third Generation Vitamin D3 Analogues as Inhibitors of Hedgehog Signaling, is published in European Journal of Medicinal Chemistry

Evrett’s manuscript, Probing Seco-Steroid Inhibition of the Hedgehog Signaling Pathway, is published in Molecular and Cellular Biochemistry.

RC’s manuscript, Structural Approach to Identify a Lead Scaffold that Targets the Translesion Synthesis Polymerase Rev1, is published in Journal of Chemical Information and Modeling.

Zu and RC’s manuscript, Small Molecule Scaffolds that Disrupt the Rev1-CT/RIR Protein-Protein Interaction, is published in Bioorganic and Medicinal Chemistry